NCT02618447

4D Phase Contrast MR: Hypertrophy in Liver Cancer

4D Phase Contrast MR: Validation and Evaluation of Hypertrophy in Liver Cancer

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators hypothesize that 4Dimensional Phase Contrast Magnetic Resonance Angiography (4D PC MRA) evaluation of portal venous flow predicts underlying liver function and hypertrophic potential in patients with liver cancer presenting for portal vein embolization (PVE). 4D PC MRA may provide a non-invasive measure of liver function that could help determine which patients could safely and successfully undergo PVE and subsequent resection of tumor. By comparing 4D PC MRA results with invasive catheter measurements the investigators will validate the flow findings. Further regression/correlation analysis with functional measures of the liver (HIDA scans), volumetrics, Doppler flow analysis, histology, and outcomes will help the investigators to determine the ability of 4D PC MRA to predict functional status and hypertrophic potential of the liver prior to PVE and hepatectomy allowing for better patient selection and reduced morbidity/mortality.

Conditions

• Liver Cancer
• Cancer of the Liver

Interventions

Type	Name	Description
DEVICE	4Dimensional Phase Contrast Magnetic Resonance Angiography	4D PC MRA is a new non-contrast MRA technique that can measure flow of blood within vessels of interest over time.
PROCEDURE	Portal vein embolization

Timeline

• Start date: 2014-08-05
• Primary completion: 2016-02-04
• Completion: 2016-02-04
• First posted: 2015-12-01
• Last updated: 2017-04-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study