NCT02618057

Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia

Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia With Lobar Consolidation or Pleural Effusion in Children

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children. The clinical course is typically self-limited and benign; however, rare cases of severe pneumonia can develop despite appropriate antibiotic therapy. The investigators aim to study the effects of prednisolone on severe M. pneumoniae pneumonia with lobar consolidation or pleural effusion in children.

Detailed description

Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia in children. The clinical course is typically self-limited and benign; however, rare cases of severe pneumonia can develop despite appropriate antibiotic therapy. The investigators aim to study the effects of prednisolone on severe M. pneumoniae pneumonia with lobar consolidation or pleural effusion in children. Participants will be randomly assigned (1:1 ratio) to receive either prednisone 1 mg/kg/d daily for 5 days or none. The primary endpoint was fever duration and analysed by intention to treat.

Conditions

• Mycoplasma Pneumoniae Pneumonia

Interventions

Type	Name	Description
DRUG	Prednisolone	PO prednisolone, 1 mg/kg/day, for 5 days
DRUG	Levofloxacin	Levofloxacin, 10mg/kg/day, IV, for 5days

Timeline

• Start date: 2016-06-01
• Primary completion: 2020-12-01
• Completion: 2020-12-01
• First posted: 2015-12-01
• Last updated: 2018-04-27

Locations

1 site across 1 country: South Korea