NCT02618005

Probiotics on Immune Function and Intestinal Microbiota in Astronauts Under Closed Microgravity Environment

Study for Evaluating the Impact of Continuous Consumption of Probiotics on Immune Function and Intestinal Microbiota in Astronauts Under Closed Microgravity Environment

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Yakult Honsha Co., LTD · Industry
• Sex: All
• Age: 25 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Human immune function and intestinal microbiota are suggested to be altered within long-duration stay in space. Accumulated evidences on earth support that Lacticaseibacillus paracasei strain Shirota (LcS) is a promising probiotic strain on improvement of immune function and intestinal microbiota. This study aims to investigate the impact of long-duration spaceflight as well as intake of LcS on the international space station (ISS), on immune system and intestinal microbiota in astronauts.

Conditions

• Immune Function and Intestinal Microbiota

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic capsule	Continuously take five capsules containing freeze-dried LcS on ISS for four weeks, from four weeks before the return (R-4W) to one day before the return (R-1d)

Timeline

• Start date: 2015-10-01
• Primary completion: 2022-04-01
• Completion: 2022-04-01
• First posted: 2015-12-01
• Last updated: 2025-11-25

Locations

1 site across 1 country: Japan