NCT02614729

The Consumption of Beef on Appetite and Cognitive Function

A Randomized Controlled Feeding, Crossover Trial to Assess the Appetitive and Cognitive Effects of Daily Beef Consumption in Healthy, Overweight Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: Female
• Age: 18 Years – 52 Years
• Healthy volunteers: Accepted

Summary

The purpose of the main study is to determine whether the daily consumption of protein-rich meals containing high quality, lean beef products improves appetite control and cognitive function during a weight maintenance diet. The purpose of the sub-study is to determine whether the daily consumption of protein-rich meals containing the same amount of high quality, lean beef products improves appetite control and cognitive function during a modest energy restriction, weight loss diet.

Detailed description

Two cross-over design studies were completed in overweight, sedentary but otherwise healthy women. For study 1, 17 participants randomly consumed 4 eucaloric diets containing standard-protein (SP; 76±1g protein/d) or high-protein (HP; 126±1g protein/d) for 7 consecutive days/treatment. The SP treatments contained all plant proteins (PLANT) or a combination of beef and plant proteins (BEEF) that were evenly distributed throughout the day (EVEN). The HP treatments were also BEEF provided as EVEN or an uneven distribution (UNEVEN) pattern. For study 2, 17 participants randomly consumed 3 energy restriction (1250 kcal/d) diets containing SP-PLANT (EVEN) and SP-BEEF (EVEN) (both, 48±1g protein/d) or HP-BEEF (EVEN) (123±1g protein/d). During day 6 of each treatment (for both studies), the participants completed a 12-h controlled-feeding, clinical testing day which included repeated appetite, satiety, food cravings, and mood questionnaires; blood sampling; and cognitive function/performance testing. During day 7 of each treatment (for both studies), the participants completed a free-living, ad libitum testing day at home/work to assess ad libitum (voluntary) daily intake and food choice. Each of the 7-day dietary patterns occurred during the follicular phase of the menstrual cycle; thus, there were 2-3 week washout periods between dietary treatments.

Conditions

• Obesity
• Poor Glycemic Control
• Dietary Interventions

Interventions

Type	Name	Description
OTHER	Standard Protein-Plant, Even Distribution (SP-PLANT-EVEN)	Diet contains all plant proteins. Meals are evenly distributed throughout the day.
OTHER	Standard Protein-Beef, Even Distribution (SP-BEEF-EVEN)	Diet contains combination of beef and plant proteins. Meals are evenly distributed throughout the day.
OTHER	High Protein-Beef, Even Distribution (HP-BEEF-EVEN)	Diet contains combination of beef and plant proteins. Meals are evenly distributed throughout the day.
OTHER	High Protein-Beef, Uneven Distribution (HP-BEEF-UNEVEN)	Diet contains combination of beef and plant proteins. Meals are unevenly distributed throughout the day.

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-05-01
• Completion: 2015-05-01
• First posted: 2015-11-25
• Last updated: 2019-07-08
• Results posted: 2019-07-08