NCT02611180

Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease

Analysis of Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 22 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Dendritic cells (DCs) serve as sentries for the immune system. DCs recognize foreign compounds (antigens) in the body, which they internalize and process. When DCs uptake foreign antigens, they migrate to secondary lymphoid organs, where the processed antigens are presented to T cells. Various DC subsets with unique cell lineages, surface protein markers, and tissue localization determinants have been identified. For example, Langerhans cells (LCs) and interstitial dendritic cells (intDCs) are DCs found in stratified epithelia, such as the skin. Though both are expressed in the skin, they differ with respect to their origin and surface protein content and can activate distinct types of immune responses. They may also have different specificities for the capture of antigens and presentation to circulating T cells. To date, it is unknown what role, if any, the different DC populations that reside or repopulate in the skin play in the development and progression of skin graft-versus-host disease (GVHD) following bone marrow transplant.

Conditions

• Acute Graft-versus-host Disease
• Acute GVHD
• Chronic Graft-versus-host Disease
• Chronic GVHD

Interventions

Type	Name	Description
PROCEDURE	Skin punch biopsy
PROCEDURE	Peripheral blood draw

Timeline

• Start date: 2015-04-30
• Primary completion: 2027-04-30
• Completion: 2027-04-30
• First posted: 2015-11-20
• Last updated: 2026-03-16

Locations

1 site across 1 country: United States