NCT02605291

Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise

The Effect of Dietary Macronutrient Manipulation and Glycogen Depleting Exercise on Substrate Oxidation at Rest and During Exercise

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: University of Birmingham · Academic / Other
• Sex: Male
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

This study will investigate the effect of dietary macronutrient manipulation on glycogen (stored carbohydrate) levels in the muscle and substrate oxidation during exercise. The investigators will investigate the hypothesis that manipulating the macronutrient content of the diet will alter the levels of glycogen in the muscle and, in turn, substrate oxidation during exercise.

Detailed description

One way to help reduce body fat is to expend more energy from the oxidation of fat as a fuel. Exercise is one way to increase fat oxidation. The extent to which exercise facilitates the use of fat as a fuel may be influenced by an individual's dietary intake. This study aims to establish the effect of dietary macronutrient manipulation on muscle glycogen levels and substrate oxidation during exercise. Participants will undertake three separate trial periods. During each trial period participants will consume a diet containing different macronutrient compositions. For each of the trials the investigators will assess how the macronutrient composition of the diet affects muscle glycogen level and substrate oxidation during exercise.

Conditions

• Dietary Manipulation

Interventions

Type	Name	Description
OTHER	Diet with a different macronutrient content A	A diet with altered macronutrient content will be provided to participants on days 4-6 of experimental arm 1.
OTHER	Diet with a different macronutrient content B	A diet with a different macronutrient content compared to arm 1 will be provided to participants on days 4-6 of experimental arm 2.
OTHER	Diet with a different macronutrient content C	A diet with a different macronutrient content compared to arms 1 and 2 will be provided to participants on days 4-6 of experimental arm 3.
OTHER	Interval treadmill running exercise	Participants will perform interval treadmill running exercise on days 4 and 5 of all experimental arms.
OTHER	Steady state treadmill running exercise	Participants will perform steady state treadmill running exercise on day 7 of all experimental arms.

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-06-01
• Completion: 2017-06-01
• First posted: 2015-11-16
• Last updated: 2018-10-11

Locations

1 site across 1 country: United Kingdom