NCT02604628

Increasing Community-acquired Pneumonia Protocol Adherence by Antibiotic Stewardship

Community-acquired Pneumonia: Increasing Protocol Adherence by Antibiotic Stewardship in a Stepped Wedge Cluster- Randomized Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 4,084 (actual)
• Sponsor: UMC Utrecht · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine the effect of a multifaceted antibiotic stewardship intervention on protocol adherence of moderate-severe community-acquired pneumonia.

Detailed description

The purpose of the study is to show a decrease in broad-spectrum antibiotics with a non-inferiority in 90-day mortality. Hospitals with a pre-intervention protocol adherence of \>70% are excluded from the primary analysis. Primary analysis will be done with a mixed effects model with a random effects for clusters and time. Crude outcomes and outcomes adjusted for potential confounders will be reported. Primary analysis will be tested one-sided for a decrease in mortality. Secondary analysis to test two-sided for mortality will be performed.

Conditions

• Community-acquired Pneumonia

Interventions

Type	Name	Description
BEHAVIORAL	Antibiotic Stewardship Intervention	The Antibiotic Stewardship Intervention will consist of education, motivating opinion leaders, adapting a pragmatic disease severity classification and prospective audit and feedback.

Timeline

• Start date: 2015-11-01
• Primary completion: 2017-11-01
• Completion: 2019-02-12
• First posted: 2015-11-13
• Last updated: 2019-02-22

Locations

12 sites across 1 country: Netherlands