NCT02604563

Aging, Geriatric Syndromes and Clonal Hematopoiesis

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,000 (estimated)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.

Conditions

• Geriatrics
• Aged
• Geriatric Syndromes
• Cardiovascular Diseases

Interventions

Type	Name	Description
OTHER	Cognitive Assessment	-Baseline and no more frequently than every 6 months until death
OTHER	Activities of Daily Living Questionnaire	* 10 items about daily functional status * Baseline and no more frequently than every 6 months until death
OTHER	Instrumental Activities of Daily Living, subscale of the OARS	* 7 items about daily functional status * Baseline and no more frequently than every 6 months until death
OTHER	Karnofsky Self-reported Performance Rating Scale	* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
OTHER	Number of Falls	* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death
OTHER	Physical Health Section, subscale of the OARS	* 13 items about comorbidity * Baseline and no more frequently than every 6 months until death
OTHER	MOS Social Activity Survey	* 4 items about social activity * Baseline and no more frequently than every 6 months until death
OTHER	Unintentional Weight Loss	* 2 items about nutrition * Baseline and no more frequently than every 6 months until death
GENETIC	Peripheral Blood Draw	-Baseline and no more frequently than every 6 months until death
GENETIC	Buccal Swab	* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush) * Baseline and no more frequently than every 6 months until death
OTHER	Heart Health and Smoking History from BRFSS questionnaire	* 7 items about heart health and smoking history * Baseline and no more frequently than every 6 months until death
OTHER	Gait Speed	* Research coordinator will test gait speed * Baseline and no more frequently than every 6 months until death
OTHER	Grip Strength	* Research coordinator will test grip strength * Baseline and no more frequently than every 6 months until death
OTHER	Height and Weight measurements	-Baseline and no more frequently than every 6 months until death
OTHER	Blood pressure measurement	-Baseline and no more frequently than every 6 months until death
PROCEDURE	Optional bone marrow biopsy	-1 optional bone marrow biopsy
PROCEDURE	Blood draw for trauma measurements	-For Arm E only

Timeline

• Start date: 2016-03-10
• Primary completion: 2030-04-30
• Completion: 2030-04-30
• First posted: 2015-11-13
• Last updated: 2025-04-25

Locations

1 site across 1 country: United States