NCT02603783

Esophageal capsaïcin Infusion and Mucosal Integrity

"Effect of capsaïcin Infusion on Esophageal Mucosal Integrity - a Role for TRPV1-mediated Neuropeptides?"

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Reflux is common, especially after large meals. In general, this can do no harm. However, if reflux occurs often and causes troublesome symptoms and or complications, it is called gastroesophageal reflux disease (GERD). Long exposure to gastric acid causes the mucosa of the esophagus to loose its integrity, which is thought to lead to the symptom of heartburn. Several food products can also impair the esophageal mucosa integrity and thereby influence reflux symptoms. One of these products is capsaicin, the pungent ingredient of red peppers. Use of capsaicin often leads to worsening of complaints in patients with GERD and can cause symptoms in healthy volunteers, possibly due to its effect on the mucosal integrity. In this study the investigators want to investigate the effect of capsaicin infusion on mucosal integrity. The investigators will evaluate mucosal impedance and the histology of the esophageal mucosa. In addition, the investigators also aim to assess the involvement of the TRPV1 receptor by evaluating the possible release of neuropeptides in the esophageal mucosa.

Conditions

• TRPV1 Protein, Human
• Capsaicin
• Electric Impedance
• Esophagus
• Intracellular Space
• Pain Measurement
• Microscopy, Electron

Interventions

Type	Name	Description
OTHER	Capsaicin	capsaicin 1,5 mg
OTHER	Placebo	0,9% saline 75 ml

Timeline

• Start date: 2015-11-01
• Primary completion: 2017-02-01
• Completion: 2017-02-01
• First posted: 2015-11-13
• Last updated: 2017-05-17

Locations

1 site across 1 country: Netherlands