NCT02602847

Study of Covalently Closed Circular DNA (cccDNA) in Liver Transplant Patients With B Virus Markers

Study of cccDNA in Liver Transplant Patients With B Virus Markers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: Hospices Civils de Lyon · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to validate in the context of liver transplantation, the interest of the cccDNA assay technique developed by the team of Professor Zoulim (INSERM U1052) on liver biopsy and correlate this assay cccDNA in hepatitis B virus (HBV) viral load and serum liver through several groups of patients at transplantation (on graft and native liver explant) and after transplantation.

Conditions

• Liver Transplantation

Interventions

Type	Name	Description
BIOLOGICAL	cccDNA assay on liver biopsy	cccDNA assay will be performed on liver biopsies at different times : During transplantation : Liver biopsy of explant and graft and virological biology Between M1 to M3 after transplantation : Liver biopsy between 1 to 3 months after transplantation M12 : Liver biopsy 12 months after transplantation

Timeline

• Start date: 2012-11-01
• Primary completion: 2018-11-01
• Completion: 2018-11-01
• First posted: 2015-11-11
• Last updated: 2019-01-11

Locations

5 sites across 1 country: France