NCT02602496

Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals

Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals Through Intake of Whole Wheat Products in Comparison With Fruits and Vegetables

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 52 (actual)
• Sponsor: University of Nebraska Lincoln · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the impact of increased intake of fruits and vegetables and whole grains on markers of inflammation and gut microbial composition. The treatment groups are 3 servings of whole grain per day; 5 servings of fruits and vegetables per day; and a control (3 servings of refined grains per day provided).

Detailed description

Literature data suggests that fruits and vegetables and whole grains containing dietary fiber and other nutrients are important for maintaining beneficial microbes in the gut. The presence of beneficial microbes in the gut may mediate the subclinical inflammation experienced in metabolic disease. In this project, overweight or obese participants with low intakes of fruits and vegetables or whole grains will increase their intake of these foods to recommended levels. Changes in markers of inflammation and gut microbiota composition will be determined to assess and compare the potential impact of these foods on metabolic disease.

Conditions

• Obesity
• Overweight

Interventions

Type	Name	Description
OTHER	Fruits and Vegetables	5 servings of fruits or vegetables
OTHER	Whole Grain	3 servings of whole grain
OTHER	Control	3 servings of refined grain

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-06-01
• Completion: 2017-07-01
• First posted: 2015-11-11
• Last updated: 2019-06-05
• Results posted: 2019-05-10

Locations

1 site across 1 country: United States