NCT02602262

Observational Study of HIV+ Deceased Donor Transplant for HIV+ Recipients

Observational Study of HIV+ Deceased Donor Solid Organ Transplant for HIV+ Recipients

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 105 (actual)
• Sponsor: Johns Hopkins University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice. Some HIV+ individuals who receive a solid organ transplant from HIV-uninfected (HIV-) donors will also be followed.

Detailed description

This is an observational study designed to evaluate safety and outcomes of solid organ transplantation in HIV+ recipients of HIV+ deceased donor organs. This study will evaluate overall survival and graft survival compared to transplantation with an HIV- organ. In addition the study will assess potential complications of organ transplant using HIV+ deceased donors - including but not limited to - HIV superinfection, incidence and severity of graft rejection, recurrence of HIV-associated nephropathy, incidence of bacterial infections, and opportunistic infections.

Conditions

• HIV Infection

Interventions

Type	Name	Description
OTHER	HIV-infected deceased donor organ	HIV-infected deceased donor organ transplant

Timeline

• Start date: 2015-11-01
• Primary completion: 2020-06-12
• Completion: 2023-06-16
• First posted: 2015-11-11
• Last updated: 2025-08-14

Locations

18 sites across 1 country: United States