NCT02600286

Ulipristal Acetate In Disease Charcot-Marie-Tooth Type of 1A

LONG-TERM EFFECTS TOLERANCE AND THE Ulipristal Acetate IN DISEASE Charcot-MARIE-TOOTH TYPE OF 1A

• Status: Terminated
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 23 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The disease Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy, for which no treatment has proved its effectiveness. It is autosomal dominant, associated with a duplication of the chromosome 17p11.2 region which leads to overexpression of the gene and the protein-peripheral myelin protein-22 (PMP22), a major component of peripheral myelin. In animals and humans, PMP22 mRNA level of glutathione S-transferase theta 2 and Cathepsin A (markers of oxidative stress), detected in a skin biopsy are markers that may play a role in the prognosis evolution of the disease. Furthermore, several studies have shown that the administration of progesterone increased the expression of PMP22 gene (measured in a skin biopsy) and worsening symptoms. In contrast, anti-progestins reduce the synthesis of PMP22 and improve symptoms in rat CMT1A. The long-term safety of anti-progesterone was evaluated for mifepristone (RU486) ulipristal acetate and (EllaOne®). Few side effects have been reported including a few cases of endometrial hyperplasia reversible upon discontinuation of treatment. With the RU486, rare cases of adrenal androgen and failure have been observed. However, EllaOne® has low antagonistic action on the glucocorticoid receptor and no action on androgen receptors. The investigators therefore believe that it will be well tolerated in humans and will reduce the synthesis of PMP22 and the action of oxidative stress by improving disability of patients.

Conditions

• CMT1A

Interventions

Type	Name	Description
DRUG	EllaOne	* 5 mg/per os of EllaOne every day through 12 months. * 10 mg/per os of EllaOne every day through 12 months. * EllaOne placebo/per os every day through 12 months.
DRUG	EllaOne placebo	* 5 mg/per os of EllaOne every day through 12 months. * 10 mg/per os of EllaOne every day through 12 months. * EllaOne placebo/per os every day through 12 months.

Timeline

• Start date: 2015-10-23
• Primary completion: 2017-11-01
• Completion: 2017-11-02
• First posted: 2015-11-09
• Last updated: 2022-07-25

Locations

5 sites across 1 country: France