NCT02599116

Gastrointestinal Microbiome Study of Appendiceal Cancer

A Cohort Study of the Gastrointestinal Microbiome in Appendiceal Cancer With Peritoneal Spread

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Mercy Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Participants will provide fecal samples pre- and post-operatively.

Detailed description

Analysis of the human microbiome is an attempt to define how changes in the human microbiome are associated with health or disease. Eligible participants scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for appendiceal cancer will provide fecal samples pre- and post-operatively. Investigators will analyze potential changes in the gastrointestinal microbiome and make comparisons to an age-matched healthy sample.

Conditions

• Pseudomyxoma Peritonei
• Appendiceal Neoplasm
• Cancer, Appendiceal

Interventions

Type	Name	Description
OTHER	Bio-specimen collection	Collection of bio-specimens (fecal sample) at 3 different time points One pre-operative collection, Two post-operative collections
OTHER	Questionnaire	Completion of lifestyle and food questionnaires (2) at each bio-specimen collection timepoint

Timeline

• Start date: 2015-12-01
• Primary completion: 2024-12-01
• Completion: 2024-12-01
• First posted: 2015-11-06
• Last updated: 2023-03-27

Locations

1 site across 1 country: United States