NCT02594930

Comparison of Two Different Techniques of Synovial Biopsy and Resistances of Cutaneous Smears in Suspected PPI

Comparison of Directed Versus Undirected Synovial Biopsy in Culture-negative Periprosthetic Joint Infections (With Preoperative Smears From the Skin) of the Knee and Evaluation of Outcome After Revision Joint Arthroplasty

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Technical University of Munich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether an undirected synovial biopsy technique has the same accuracy in detecting periprosthetic joint infection in the knee as an arthroscopic assisted directed synovial biopsy technique.

Detailed description

Successful treatment of an infected joint arthroplasty depends on correctly identifying the responsible pathogens. The value of a preoperative biopsy remains controversial. We compared the sensitivity and specificity of two techniques of synovial biopsy of knee joint arthroplasties suspicious for infection and asked whether the results correlate with intraoperative findings at revision.

Conditions

• Infection of Total Knee Joint Prosthesis

Interventions

Type	Name	Description
PROCEDURE	synovial biopsy of total knee arthroplasty	synovial biopsies are taken via two different techniques in the same patient to allow direct comparison of results

Timeline

• Start date: 2015-09-01
• Primary completion: 2017-09-01
• Completion: 2017-11-01
• First posted: 2015-11-03
• Last updated: 2016-10-19

Locations

1 site across 1 country: Germany