NCT02593799

Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 363 (actual)
• Sponsor: General Hospital of Shenyang Military Region · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.

Detailed description

Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.

Conditions

• Liver Cirrhosis
• Esophageal and Gastric Varices

Interventions

Type	Name	Description
PROCEDURE	Endoscopy	Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.

Timeline

• Start date: 2015-05-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2015-11-02
• Last updated: 2019-02-04

Locations

17 sites across 1 country: China