NCT02593344

Peripheral Endothelial Function in Asthmatic Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 113 (actual)
• Sponsor: Hopital Foch · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to assess the peripheral endothelial function in adult asthmatic patients and the relationship between the peripheral endothelial function and the pulmonary function.

Detailed description

The primary criteria is the peripheral endothelial function that will be assessed by the measure of flow-mediated dilation (reactive hyperemia-peripheral artery tone index). The pulmonary function will be assessed by the measures of the FEV1, the forced vital capacity (FVC) and the expiratory flow between 25% and 75% (FEF25-75%). The relationship between these parameters of the pulmonary function and the peripheral endothelial function will be analyzed. In addition, a relationship between peripheral endothelial function and the level of asthma control (Asthma Control Test (ACT)), the cardiovascular risk factors (SCORE INdex) and the treatment for asthma (controllers) will be also assessed.

Conditions

• Endothelial Function

Interventions

Type	Name	Description
DEVICE	Endopat	measure of peripheral endothelial function by the reactive hyperemia-peripheral artery tone index with a specific device (Endopat)

Timeline

• Start date: 2012-12-13
• Primary completion: 2015-04-09
• Completion: 2015-04-09
• First posted: 2015-11-02
• Last updated: 2018-10-03

Locations

2 sites across 1 country: France