NCT02592902

Recurrent Respiratory Papillomatosis and Extraesophageal Reflux

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University Hospital Ostrava · Academic / Other
• Sex: All
• Age: 1 Year – 75 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).

Detailed description

Recurrent respiratory papillomatosis (RRP) is a chronic viral disease, which affects children and adults as well. It is characterised by grow of squamous cell tumours on mucosa of aerodigestive tract, with predilection for the larynx. The disease is caused by the human papillomavirus (HPV). However, in contrast to the low incidence of RRP, HPV prevalence is common. It is indicated that other factors may contribute to the pathogenesis of RRP. One such factor might be extraesophageal reflux (EER). We investigated whether patients with RRP suffer more often from EER.

Conditions

• Recurrent Respiratory Papillomatosis
• Extra Oesophageal Reflux
• Laryngeal Cyst

Interventions

Type	Name	Description
PROCEDURE	Surgical collection of histology specimen	Collection of a histology specimen from the vocal cords and rear laryngeal commissure
PROCEDURE	Performance of immunohistochemical analysis	Immunohistochemical analysis - presence of pepsin, HPV 6 and 11, HSV 2 and chlamydia trachomasis

Timeline

• Start date: 2014-04-01
• Primary completion: 2018-08-01
• Completion: 2018-09-01
• First posted: 2015-10-30
• Last updated: 2019-02-20

Locations

1 site across 1 country: Czechia