NCT02590497

Correlation Between the Genetic and Neuroimaging Signatures in Newly Diagnosed Glioblastoma Patients Before Surgery

The Correlation Between the Genetic and Neuroimaging Signatures in Newly Diagnosed Glioblastoma

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Ohio State University Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies the correlation between the genetics and brain images of patients with newly diagnosed glioblastoma before surgery. The genetic characteristics of a tumor are an important way to predict how well it will respond to treatment. Imaging, using magnetic resonance imaging (MRI), takes detailed pictures of organs inside the body, and may also provide information that helps doctors predict how brain tumors will respond to treatment. If MRI can provide doctors with similar information about the tumor as the tumor's genes, it may be able to be used to predict tumor response in patients whose tumors cannot be reached by surgery or biopsy to get tissue samples.

Detailed description

PRIMARY OBJECTIVES: I. Determine the correlation between the genetic and neuroimaging signature of glioblastoma. II. Determine the correlation between the neuroimaging signature of glioblastoma and prognosis. OUTLINE: Patients undergo MRI before and after gadolinium contrast administration, including 3-dimensional (3D) volumetric T1-weighted sequence, fluid attenuated inversion recovery (FLAIR) sequence, diffusion weighted imaging, and perfusion MRI. Tissue samples are also analyzed for the tumor genetic profile.

Conditions

• Glioblastoma

Interventions

Type	Name	Description
PROCEDURE	Diffusion Weighted Imaging	Undergo diffusion weighted MRI
DRUG	Gadolinium	Undergo gadolinium-enhanced MRI
OTHER	Laboratory Biomarker Analysis	Tissue genetic analysis
PROCEDURE	Magnetic Resonance Imaging	Undergo gadolinium-enhanced MRI
PROCEDURE	Magnetic Resonance Imaging	Undergo 3D volumetric T1-weighted sequence
PROCEDURE	Magnetic Resonance Imaging	Undergo FLAIR sequence
PROCEDURE	Perfusion Magnetic Resonance Imaging	Undergo perfusion MRI

Timeline

• Start date: 2016-03-20
• Primary completion: 2017-10-26
• Completion: 2017-10-26
• First posted: 2015-10-29
• Last updated: 2018-01-31