NCT02587468

Bioavailability and Absorption Kinetics of Phenolic Compounds and Specific Vitamins

Bioavailability and Absorption Kinetics of Phenolic Compounds and Specific Vitamins of a Commercially Available, Encapsulated Nutraceutical (Juice Plus+®)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Green Beat · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder ENDPOINTS * Absorption kinetics of phenolic compounds in plasma * Bioavailability of vitamins C, E, and carotenoids into plasma Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).

Detailed description

Phytonutrients are regarded to play an important role in many health-related issues like: * Improvement of redox balance * Anti-inflammatory effects * Prevention of chronic diseases like CVD, stroke, diabetes II, Alzheimer´s, AMD, and certain forms of cancer * Beneficial effects on human´s microbiome Therefore it is of scientific interest whether this product provides absorbable phytonutrients/phenolics and vitamins to support mechanistic explanations for the beneficial outcomes observed in the past after intake of Juice Plus+®. GOAL To identify absorption kinetics and bioavailability of phenolic compounds and specific vitamins from encapsulated Juice Plus+® powder MERITS * This study would reveal knowledge whether and to which extent specific vitamins and phenolic compounds are absorbed, including absorption kinetics/metabolism. * Data of this study may provide support for mechanistic arguments on the beneficial clinical outcomes observed and published in the past. ENDPOINTS * Absorption kinetics of phenolic compounds in plasma * Bioavailability of vitamins C, E, and carotenoids into plasma Absorption kinetics of phytonutrients: * Open-, one-arm study, absorption kinetics over 10 hours * 5 blood sample collections: baseline (= 0); 1hr, 2hrs, 5hrs and 10 hours after intake of 3 capsules * Wash-out of all food supplements and dietetic foodstuff: 2 weeks * Wash-out of phytonutrients: 48 hours before baseline sampling, accomplished via a phytonutrient-poor diet. Bioavailability of vitamins C, E, A and carotenoids: * Open-, one-arm study over 8 weeks * 2 blood sample collections: at baseline (2 weeks after the phenolics experiment) and after 8-weeks * Wash-out of all food supplements and dietetic foodstuff: 4 weeks, 2 weeks before the phenolics experiment + another 2 weeks Subjects: 20 healthy subjects from Graz region, meeting all inclusion criterions (see underneath).

Conditions

• Healthy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Juice Plus+(R)	before-after comparison of plasma phenolics

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-06-01
• Completion: 2017-07-01
• First posted: 2015-10-27
• Last updated: 2017-08-01

Locations

2 sites across 1 country: Austria