NCT02584413

Hypotonia and Neurofibromatosis Type 1 (NF1) Glioma

Hypotonia as a Clinical Predictor of Optic Pathway Glioma in Children With Neurofibromatosis Type 1

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 1 Year – 7 Years
• Healthy volunteers: Not accepted

Summary

Currently, optic pathway gliomas (OPG) are detected based on abnormal findings made during annual ophthalmologic exams. However, because these exams are annual, it is possible for healthcare providers to miss the point at which a child's vision begins to decline (potentially indicating an OPG). If at-risk children are screened for hypotonia early in life, those children who are hypotonic may undergo magnetic resonance imaging (MRI) to evaluate for OPG before they are showing ophthalmologic symptoms. This would enable healthcare providers to discover vision loss earlier and treat symptomatic OPGs earlier, thereby allowing us a better chance of preventing further vision loss in children with OPGs.

Conditions

• Neurofibromatosis Type 1

Interventions

Type	Name	Description
DEVICE	Magnetic resonance imaging	-Standard of care
DRUG	Gadolinium contrast	-Standard of care

Timeline

• Start date: 2013-04-16
• Primary completion: 2019-02-07
• Completion: 2019-02-07
• First posted: 2015-10-22
• Last updated: 2019-09-03

Locations

1 site across 1 country: United States