NCT02583061

Toronto Gestational Glucose Tolerance Cohort

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 350 (estimated)
• Sponsor: Mount Sinai Hospital, Canada · Academic / Other
• Sex: Female
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

In this prospective observational cohort study, women representing the full spectrum of gestational glucose tolerance status are undergoing longitudinal cardiometabolic characterization at regular intervals in the years after the index pregnancy.

Detailed description

In this prospective observational cohort study, women reflecting the full spectrum of glucose tolerance in pregnancy (from gestational diabetes mellitus (GDM) to lesser degrees of gestational glucose intolerance to those with completely normal glucose tolerance) are being recruited in late 2nd trimester. This cohort of women thus carries a broad range of risk for the future development of type 2 diabetes (T2DM) and cardiovascular disease. At regular intervals in the years after the index pregnancy, this cohort of women is undergoing serial cardiometabolic characterization, including assessment of glucose tolerance, beta-cell function and insulin sensitivity. The longitudinal changes over time in this cohort should provide insight into the early pathophysiology and natural history of T2DM and cardiovascular disease.

Conditions

• Type 2 Diabetes, Gestational Diabetes, Pre-diabetes

Interventions

Type	Name	Description
OTHER	There is no intervention. An exposure of interest is glucose tolerance status in pregnancy

Timeline

• Start date: 2003-09-01
• Primary completion: 2029-10-01
• Completion: 2029-10-01
• First posted: 2015-10-21
• Last updated: 2025-05-09

Locations

1 site across 1 country: Canada