Trials / Completed
CompletedNCT02581917
Metabolic Changes in Blood Samples From Patients With Acute Myeloid Leukemia
A Study of the Metabolic Changes in Leukemia Cells Following Treatment in AML Patients
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 14 (actual)
- Sponsor
- Wake Forest University Health Sciences · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
This research trial studies metabolic changes in blood samples from patients with acute myeloid leukemia. Studying samples of blood from patients with acute myeloid leukemia in the laboratory may help doctors learn more about cancer and the development of drug resistance.
Detailed description
PRIMARY OBJECTIVES: I. To determine the metabolic adaptations that occur following exposure to standard chemotherapeutic agents using peripheral blood mononuclear cells from acute myeloid leukemia (AML) patients. OUTLINE: Patients undergo collection of peripheral blood mononuclear cell (PBMC) samples for analysis via cell isolation, glycolytic flux and oxygen consumption assays, viability assays, and western blot at baseline, 24, 48, and 72 hours after starting chemotherapy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Cytology Specimen Collection Procedure | Undergo collection of PBMC samples |
| OTHER | Laboratory Biomarker Analysis | Undergo metabolic analysis |
Timeline
- Start date
- 2017-04-21
- Primary completion
- 2021-04-01
- Completion
- 2022-04-30
- First posted
- 2015-10-21
- Last updated
- 2022-10-20
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02581917. Inclusion in this directory is not an endorsement.