NCT02577692

Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers

Impact of Inspired Oxygen on Oxidative Stress and Breath Volatile Organic Compound Composition in Healthy Volunteers: A Randomized Controlled Cross-over Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Klinikum der Universitaet Muenchen, Grosshadern · Academic / Other
• Sex: Male
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

High inspiratory oxygen fractions are known to induce oxidative stress and lipid peroxidation. The degrading products of oxidative stress induced lipid peroxidation are in part volatile and appear in breath where they can be measured non-invasively. However, there is lack of knowledge on the correlation of blood and breath biomarkers of oxidative stress. This study aims to investigate the effects of a high inspiratory oxygen fraction on oxidative stress in healthy volunteers. The primary outcome is the appearance of exhaled breath biomarkers of oxidative stress by electrochemical sensors and ion mobility mass spectrometry. Secondary outcomes are changes in oxidative stress biomarkers in blood and their relationship to breath biomarkers.

Conditions

• Oxidative Stress

Interventions

Type	Name	Description
OTHER	Oxygen	breathing oxygen
OTHER	Ambient	breathing ambient air

Timeline

• Start date: 2016-05-01
• Primary completion: 2019-11-01
• Completion: 2019-11-01
• First posted: 2015-10-16
• Last updated: 2018-03-08

Locations

1 site across 1 country: Germany