NCT02575495

A Randomized Control Trial of Antibiotic Treatment Duration For Asymptomatic Bacteriuria After Kidney Transplantation

A Pilot Randomized Control Study of Shortening Antibiotic Treatment Duration For Asymptomatic Bacteriuria Within A Month After Kidney Transplantation

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 15 Years
• Healthy volunteers: Not accepted

Summary

The major hypothesis to be tested is that there was no difference in the clinical outcome between 7(short-course) and 14(traditional-course) days of antibiotic treatment for asymptomatic bacteriuria early after kidney transplantation.

Detailed description

Introduction: Treatment of asymptomatic bacteriuria is a common practice in renal transplant centers leading to prolong exposure of antimicrobial agents with long hospital length of stay. The duration of antibiotics treatment in this condition have never been proposed. Objective: To evaluate the proper duration of antibiotic treatment for asymptomatic bacteriuria early (less than 1 month) after kidney transplantation Method: This is a prospective, randomized, open labeled, single center study using intention to treat analysis. Patients will be identified and after informed consent is obtained, will be randomized to receive 7 or 14 days course of antibiotics.

Conditions

• Kidney Transplantation
• Bacteriuria
• Asymptomatic Infections

Interventions

Type	Name	Description
DRUG	7 days course of antibiotic treatment	start specific intravenous antibiotic therapy as microbiological susceptibility from urine culture for 7 days
DRUG	14 days course of antibiotic treatment	start specific intravenous antibiotic therapy as microbiological susceptibility from urine culture for 14 days

Timeline

• Start date: 2015-02-01
• Primary completion: 2016-01-01
• Completion: 2016-02-01
• First posted: 2015-10-14
• Last updated: 2016-03-16

Locations

1 site across 1 country: Thailand