NCT02575027

Palliative 4pi Radiotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

4π Radiotherapy for Recurrent Glioblastoma Multiforme: A Feasibility Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Jonsson Comprehensive Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies the feasibility of palliative 4pi radiotherapy in treating patients with glioblastoma multiforme that has come back after standard chemoradiation. A new radiotherapy delivery planning system, called 4pi radiotherapy, may help improve radiation delivery by improving dose coverage to the treatment target, while reducing the dose to surrounding normal tissues.

Detailed description

PRIMARY OBJECTIVES: I. To determine the accuracy of dose delivery and patient comfort with treatment time. II. To evaluate normal tissue dose volume statistics and compare to standard planning. OUTLINE: Patients undergo 4pi radiation simulation and planning followed by 5 to 10 daily fractions of 4pi palliative radiotherapy. If an acceptable plan cannot be achieved using 4pi planning, then the patient will be treated with standard radiation therapy planning for palliative re-irradiation. After completion of study treatment, patients are followed up at 6 weeks.

Conditions

• Glioblastoma
• Recurrent Brain Neoplasm

Interventions

Type	Name	Description
RADIATION	Palliative Radiation Therapy	Undergo 4pi palliative radiotherapy
OTHER	Questionnaire Administration	Ancillary studies
RADIATION	Radiation Therapy Treatment Planning and Simulation	Undergo 4pi radiation simulation and planning

Timeline

• Start date: 2014-11-12
• Primary completion: 2018-06-20
• Completion: 2018-06-20
• First posted: 2015-10-14
• Last updated: 2019-02-28

Locations

1 site across 1 country: United States