NCT02572778

Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer

Establishment of Primary Patient-derived Xenograft Models of Tumor From Patients With Head and Neck Cancer for Preclinical Evaluation of Targeted Therapies.

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 40 (estimated)
• Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators want to have a collection of fresh primary or recurrent tumor tissue for establishment of patients-derived xenografts in order to: generate a biobank of in vivo patient xenografts representing the different subgroups of tumors for head and neck cancer * perform genetic and transcriptional profiling of the primary, metastatic tumors and xenograft tumors * evaluate the efficacy of new targeted agents, whether or not in combination with standard treatment options * evaluate biomarkers of drug sensitivity * study primary and secondary (acquired) resistance in these models

Conditions

• Squamous Cell Carcinoma of the Head and Neck

Interventions

Type	Name	Description
PROCEDURE	Local biopsy in the tumor	A tumor biopsy of 0.5 cm2 or more will be collected from every patient during surgery or endoscopy after informed consent and if there is enough material after review by the pathologist.

Timeline

• Start date: 2015-09-01
• Primary completion: 2025-12-01
• Completion: 2025-12-01
• First posted: 2015-10-09
• Last updated: 2024-12-03

Locations

1 site across 1 country: Belgium