NCT02572154

Sperm DNA Fragmentation in Recurrent Pregnancy Loss

Male Factor in Early Recurrent Pregnancy Loss : Study of Sperm DNA Fragmentation in Patients With Unexplained Recurrent Pregnancy Loss.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: University Hospital, Toulouse · Academic / Other
• Sex: Male
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

In human, 2% of couples experimented Recurrent pregnancy loss (RPL). Currently, while etiological investigations were performed, 40 to 50 % of RPL were unexplained. In animals' studies, several studies have underlined the importance of sperm quality for a normal embryo development. In human, epidemiological studies have demonstrated that several male risk factors have effects on development (male mediated development toxicology). However, few studies have explored sperm DNA fragmentation on embryo development but after in vitro fertilization. In natural pregnancy only rare studies have been performed but with different populations definitions and different methods of sperm exploration. In this context sperm DNA fragmentation exploration appears justified. The present study purpose to conduct a case - control study in order to research paternal role in RPL.

Conditions

• RECURRENT PREGNANCY LOSS

Interventions

Type	Name	Description
OTHER	Blood and sperm samples	20 ml of blood and sperm samples for sperm DNA fragmentation exploration

Timeline

• Start date: 2012-09-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2015-10-08
• Last updated: 2025-12-15

Locations

3 sites across 1 country: France