NCT02569905

Effect of Parecoxib Sodium and Flurbiprofen Injection on Postoperative Shivering

Tumor Hospital of Guangxi Medical University, China

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 166 (actual)
• Sponsor: Guangxi Medical University · Academic / Other
• Sex: All
• Age: 21 Years – 62 Years
• Healthy volunteers: Accepted

Summary

Shivering is an early postoperative complication during the postoperative recovery period, and there is no clear consensus about the best way for its prevention. The aim of the study was to compare the efficacy and accompanying side effects of prophylactic flurbiprofen with that of parecoxib or placebo for reducing postoperative shivering.

Detailed description

154 patients with American Society of Anesthesiologists physical status I-II, who were scheduled for colorectal operation under general anesthesia, were randomly assigned to receive flurbiprofen (Group F), parecoxib sodium (Group P ) or normal saline(Group S)40min before the end of surgery. Hemodynamic parameters were monitored. The occurrence of shivering postoperative nausea and vomiting were recorded during the recovery period. And visual analogue score (VAS) and ramsy sedation scale (RSS) were also recorded.

Conditions

• Postoperative Shivering

Interventions

Type	Name	Description
DRUG	parecoxib sodium	parecoxib sodium 40mg
DRUG	flurbiprofen	flurbiprofen 50mg
DRUG	saline	normal saline

Timeline

• Start date: 2014-04-01
• Primary completion: 2015-04-01
• Completion: 2015-04-01
• First posted: 2015-10-07
• Last updated: 2015-10-27

Locations

1 site across 1 country: China