Trials / Completed
CompletedNCT02568735
Dexketoprofen and Etoricoxib in Patients Undergoing Hip Arthroplasty
The Central Nervous Penetration of Dexketoprofen and Etoricoxib and Their Effect on Pain and Inflammatory Reaction in Patients Undergoing Hip Arthroplasty
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 24 (actual)
- Sponsor
- Kuopio University Hospital · Academic / Other
- Sex
- All
- Age
- 40 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
The main purpose of this study was to determine the plasma and central nervious system pharmacokinetics of dexketoprofen and etoricoxib. The secondary aim was to asses their effect on the concentrations of interleukin 6, prostaglandin E2 and other proinflammatory markers both in plasma and cerebrospinal fluid. Thirdly, the investigators aimed to evaluate their efficacy in postoperative pain treatment.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Dexketoprofen | After total hip replacement surgery patient were given either etoricoxib or dexketoprofen |
| DRUG | Etoricoxib | After total hip replacement surgery patient were given either etoricoxib or dexketoprofen |
Timeline
- Start date
- 2013-01-01
- Primary completion
- 2014-12-01
- Completion
- 2014-12-01
- First posted
- 2015-10-06
- Last updated
- 2016-05-03
Source: ClinicalTrials.gov record NCT02568735. Inclusion in this directory is not an endorsement.