NCT02561533

Detection of BRAF Mutation on FNAB From Papillary Thyroid Carcinoma

Immunohistochemical Detection of the BRAFV600E Mutation on Cytological Specimen in PTC

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Immunohistochemical detection of the BRAF-V600E mutation on pre-operative fine needle aspiration biopsy (FNAB) from patients suspected for papillary thyroid carcinoma, using the mutation specific antibody VE1.

Detailed description

The BRAF mutation is reported to be present in approximately 50% of papillary thyroid carcinomas (PTC). The mutation has been associated with poor prognosis and more advanced disease stage. Therefore, pre-operative detection of the BRAF-V600E mutation may be of clinical interest in order to individualize treatment of patients with BRAF positive PTC. FNABs are performed immediately before the thyroid operation, and BRAF-V600E detection using VE1 is performed on clots. The VE1 stain is compared to the mutation status of the removed cancer or control tissue using the Cobas test.

Conditions

• Papillary Thyroid Carcinoma

Interventions

Type	Name	Description
OTHER	BRAF detection on fine needle aspiration biopsy (FNAB)

Timeline

• Start date: 2014-12-01
• Primary completion: 2017-07-01
• Completion: 2017-07-01
• First posted: 2015-09-28
• Last updated: 2017-07-14

Locations

1 site across 1 country: Denmark