NCT02560207

Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.

Does Continuous Cefotaxime Administration Improve Time to Attainment and Maintenance of Target Drug Levels in Critically Ill Patients?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill patients will be randomized to intermittent infusion or continuous infusion of cefotaxime.

Detailed description

Critically ill patients have other pharmacokinetic/pharmacodynamic profiles than healthy volunteers. Suboptimal, both under- and overdosing of antibiotics is an important threat in this patient category. Given the time-dependent character of beta-lactam antibiotics continuous dosing as opposed to traditional intermittent dosing is likely to render better target attainment and maintenance and might improve clinical outcome.

Conditions

• Critically Ill

Interventions

Type	Name	Description
DRUG	Cefotaxime	To assess the influence of administration route on target attainment cefotaxime is administered via two IV routes.

Timeline

• Start date: 2015-11-01
• Primary completion: 2016-06-01
• Completion: 2016-09-01
• First posted: 2015-09-25
• Last updated: 2016-10-27

Locations

1 site across 1 country: Netherlands