NCT02555566

Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy - The TRANSPLANT-EETs Study

Role of Epoxyeicosatrienoic Acids in Chronic Allograft Nephropathy

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Endothelial lesions within the transplanted kidney are a major determinant of chronic allograft nephropathy. Epoxyeicosatrienoic acids (EETs) are endothelium-derived hyperpolarizing factors with anti-inflammatory, antiproliferative and vasodilator properties. The main goal of the investigators' study is to evaluate whether genetic polymorphisms of specific enzymes responsible for the bioavailability of EETs are associated with post-transplant kidney function. To this end, 80 kidney transplant recipients will be included. Prespecified genetic polymorphisms of CYP 2J2, CYP 2C8, CYP 2C9, CYP 2C9, CYP 2C19 and EPHX2 will be determined. Kidney function will be recorded 3, 6, 12 and 36 months after transplantation. Flow-mediated dilatation, EETs and circulating biomarkers of endothelial function will be measured in the radial artery. The expected results of this study to provide preliminary evidence supporting a beneficial role of an increase in the bioavailability of EETs in kidney transplant recipients.

Conditions

• Kidney Transplant Recipients

Interventions

Type	Name	Description
PROCEDURE	Blood sampling	Blood sampling is done for Kidney transplant recipients for evaluation of the polymorphisms and EETs dosage
PROCEDURE	flow-mediated distal stimulation of the forearm radial artery by cutaneous heating	Flow-mediated distal stimulation of the forearm radial artery by cutaneous heating for Kidney transplant recipients

Timeline

• Start date: 2014-03-01
• Primary completion: 2016-12-01
• Completion: 2016-12-01
• First posted: 2015-09-21
• Last updated: 2016-12-07

Locations

1 site across 1 country: France