NCT02555332

Maternal Thyroid Function in Early Pregnancy and Their Relationship With Gestational Diabetes Mellitus

Maternal TSH Level and TPOAb Status in Early Pregnancy and Their Relationship to the Risk of Gestational Diabetes Mellitus

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7,729 (actual)
• Sponsor: Shanghai First Maternity and Infant Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Not accepted

Summary

This study was conducted to analyze the role of TSH level and TPOAb status in early pregnancy and use this information in assessment of the risk of gestational diabetes mellitus at different weeks of gestation when the FT4 level is normal.

Detailed description

A total of 7,729 women with singleton pregnancies who were receiving antenatal care at Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine between December 2012 and March 2014 were included in the study. All these women underwent screening for thyroid function (TSH,FT4 and TPOAb) at the first antenatal visit and a 75 g oral glucose tolerance test at 24-28 weeks of gestation. The correlation between a combination of TSH level and TPOAb status and the risk of gestational diabetes mellitus was analyzed.

Conditions

• Pregnancy
• Thyroid Function Tests
• Gestational Diabetes Mellitus

Interventions

Type	Name	Description
OTHER	75g oral glucose tolerance test (OGTT)	All these women underwent the 75g oral glucose tolerance test (OGTT) at 24-28 weeks of gestation.

Timeline

• Start date: 2012-12-01
• Primary completion: 2014-03-01
• Completion: 2014-03-01
• First posted: 2015-09-21
• Last updated: 2015-09-21