Trials / Completed
CompletedNCT02551276
Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy
Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 42 (actual)
- Sponsor
- University of Copenhagen · Academic / Other
- Sex
- Male
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Salbutamol | |
| DRUG | Placebo | |
| OTHER | Resistance training |
Timeline
- Start date
- 2013-11-01
- Primary completion
- 2014-11-01
- Completion
- 2015-11-01
- First posted
- 2015-09-16
- Last updated
- 2016-03-15
Source: ClinicalTrials.gov record NCT02551276. Inclusion in this directory is not an endorsement.