Trials / Completed
CompletedNCT02551029
fMRI and Visceral Perception Upon Capsaicin Infusion
Brain and Brainstem Activation Following Duodenal Nociceptive Stimulation With Capsaicin, an Exploratory High-resolution fMRI Study in Healthy Volunteers
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 19 (actual)
- Sponsor
- Maastricht University Medical Center · Academic / Other
- Sex
- Female
- Age
- 18 Years – 65 Years
- Healthy volunteers
- Accepted
Summary
Brain imaging has shown abnormal brain activations in response to visceral stimulation in patients with the Irritable Bowel Syndrome (IBS) and Functional Dyspepsia (FD). To investigate the possible role of the Nucleus of the Solitary Tract (NTS), the primary relay station in the brainstem for vagal afferents, its activation in IBS and functional dyspepsia patients will be evaluated. Prior to this, an exploratory study in healthy volunteers will be conducted. This will be the first high magnetic field fMRI study (7T) evaluating the possible role of NTS activation in visceral abdominal pain. Moreover, this will be the first pharmacological fMRI study using duodenal capsaicin infusion as a chemical stimulus, which is more physiological than mechano-stimulation in the upper gastrointestinal tract.
Conditions
- Irritable Bowel Syndrome
- Colonic Diseases, Functional
- Dyspepsia
- Gastrointestinal Diseases
- Abdominal Pain
- Visceral Pain
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Capsaicin | |
| OTHER | Placebo |
Timeline
- Start date
- 2016-02-01
- Primary completion
- 2019-07-26
- Completion
- 2019-07-26
- First posted
- 2015-09-16
- Last updated
- 2020-06-09
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02551029. Inclusion in this directory is not an endorsement.