NCT02549144

Effects of a Large Increase in Dietary Fats and Cholesterol on HDL Composition and Function in Healthy Subjects

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 14 (actual)
• Sponsor: Azienda Ospedaliero, Universitaria Pisana · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week low-fat/low-cholesterol (LFLC) normocaloric diet.

Detailed description

HDL particles can change their composition and function in response to a variety of pathological conditions and environmental stimuli. It has been previously shown that a western diet is able to drastically modify biochemical composition, anti-inflammatory and anti-oxidant properties of HDL in animals. In humans little is known on the role of diet on HDL function and composition.

Conditions

• Lipids

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Low fat/cholesterol diet	The low fat/cholesterol diet had 10% calories from fat and 150-200 mg of cholesterol per day.
DIETARY_SUPPLEMENT	High fat/cholesterol diet	The high fat/cholesterol diet had 40% calories from fat and 250-300 mg of cholesterol per day

Timeline

• Start date: 2015-01-01
• Primary completion: 2015-11-01
• Completion: 2015-12-01
• First posted: 2015-09-15
• Last updated: 2022-01-06

Locations

1 site across 1 country: Italy