NCT02548156

Intra Oral Kinetics of Fluoride Containing Dentifrices

Intra-oral Kinetics of Fluoride Containing Dentifrices in a Modified Saliva Clearance Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 29 (actual)
• Sponsor: GlaxoSmithKline · Industry
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of fluoride and calcium ions in saliva over 60 minutes after a single brushing with US marketed fluoridated dentifrices and following a dietary acid challenge post 60 minutes of brushing with study treatment.

Conditions

• Tooth Erosion

Interventions

Type	Name	Description
OTHER	Test Dentifrice	Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
OTHER	Reference Dentifrice	Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
OTHER	Comparator Dentifrice	Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3
OTHER	Orange Juice	Teeth will be rinsed with orange juice followed by rinsing with de-ionised water in test dentifrice and comparator dentifrice arms.
OTHER	De-ionised water	Teeth will be rinsed with de-ionised water followed by reference dentifrice and followed by rinsing with orange juice in test dentifrice and comparator dentifrice arms.

Timeline

• Start date: 2015-09-01
• Primary completion: 2015-10-01
• Completion: 2015-10-01
• First posted: 2015-09-14
• Last updated: 2017-01-18
• Results posted: 2016-07-27

Locations

1 site across 1 country: United Kingdom