NCT02546453

Use of Specific Genetic Alteration s of Tumoral Cells Identified by the Next Generation Sequencing Techniques (NGS) to Follow Peripheral Samples of Children With Metastatic and/or High Risk Solid Tumor - NGSKids

Use of Specific Genetic Alteration s of Tumoral Cells Identified by NGS to Follow Peripheral Samples of Children With Metastatic and/or High Risk Solid Tumor -

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Institut Curie · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The search for genetic alterations in primary tumor by NGS techniques followed by the detection of these alterations in circulating tumor DNA and/or CTC/DTC present in peripheral samples (blood, cerebrospinal fluid, bone marrow, possibly urine) collected during several steps and after the treatment could be a tool to monitor the response during and after the treatment.

Conditions

• Metastatic and/or High Risk Solid Tumor of Children

Interventions

Type	Name	Description
BIOLOGICAL	Tumoral specific genetic alterations	A buccal swab and a blood sample will be used at the diagnostic to identify the specific genetic alterations of tumoral cells.
BIOLOGICAL	Tumoral specific genetic alterations	Collection of blood (maximum 9 samples of 3 to 5 ml), bone marrow (maximum 3 samples of 3 to 5 ml) and cerebral spinal fluid (maximum 3 samples 500µl to 1ml).

Timeline

• Start date: 2014-09-01
• Primary completion: 2021-01-01
• Completion: 2021-01-01
• First posted: 2015-09-10
• Last updated: 2024-01-31

Locations

1 site across 1 country: France