NCT02546219

a4b7 Integrin in Eosinophilic Esophagitis

Investigating the Role of a4b7 Integrin as a Therapeutic Target in Eosinophilic Esophagitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 16 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The overall objective of this preclinical study is to further the investigators mechanistic understanding of the role that the α4β7 and mucosal addressin cell adhesion molecule (MAdCAM-1) pathway plays in mediating eosinophil recruitment in EoE. To accomplish this, the investigators aim to (1) determine the baseline and dynamic patterns of α4β7 integrin expression on circulating and tissue eosinophils in EoE and in the setting of non-EoE esophageal eosinophilia (e.g., reflux esophagitis) and (2) determine the complete profile of eosinophil integrin molecules that may play a role in active EoE.

Conditions

• Eosinophilic Esophagitis

Interventions

Type	Name	Description
OTHER	Eosinophil isolation and characterization.	Peripheral blood and esophageal biopsies will be obtained from study subjects for further analysis of eosinophils integrin profiles.

Timeline

• Start date: 2016-03-01
• Primary completion: 2018-12-31
• Completion: 2018-12-31
• First posted: 2015-09-10
• Last updated: 2019-02-21

Locations

1 site across 1 country: United States