NCT02544269

Hemodynamic Effect of Lumbosacral Plexus Blockade Versus Spinal Anesthesia

Surgical Anesthesia for Elective Hip Surgery - Hemodynamic Effect of Lumbosacral Plexus Blockade Compared to Spinal Anesthesia

• Status: Terminated
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 50 Years
• Healthy volunteers: Not accepted

Summary

The study evaluates the hemodynamic effect of lumbosacral plexus blockades versus spinal anesthesia for hip replacement. Half of participants will receive lumbosacral plexus blockade and the other half will receive continuous spinal anesthesia.

Detailed description

Patients for total hip replacement will be randomized for surgical anesthesia with either lumbosacral plexus blockade or continuous spinal anesthesia. All patients will receive central venous, arterial and spinal catheters. Hemodynamics will be monitored with transpulmonary thermodilution and pulse contour analysis. Perineural injection of study medicine around the lumbar and sacral plexus will be performed guided by ultrasound and nerve stimulation. Study medicine will be injected in divided doses in the spinal catheter. Treatment will be blinded using double-dummy technique. After the first intrathecal dose of study medicine, the hemodynamic response will be monitored for 60 minutes. Patients will then be transferred to the operating room, where total hip replacement will be performed in lumbosacral plexus blockade or spinal anesthesia according to randomization.

Conditions

• Total Hip Replacement

Interventions

Type	Name	Description
PROCEDURE	Ropivacaine	Lumbosacral plexus blockade with ropivacaine.
PROCEDURE	Bupivacaine	Regional anesthesia with bupivacaine titrated to the lowest effective dose

Timeline

• Start date: 2016-06-01
• Primary completion: 2017-01-25
• Completion: 2017-01-25
• First posted: 2015-09-09
• Last updated: 2017-05-05

Locations

1 site across 1 country: Denmark