NCT02543177

Optimised Procedure in Patients With NSTEMI and CKD

Optimised Procedure in Patients With an Acute Non-ST-segment Elevation Myocardial Infarction and Acute or Chronic Kidney Disease

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 1 (actual)
• Sponsor: RWTH Aachen University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Aim of the study is the determination of the ideal timepoint for the treatment of patients with acute Non-ST-segment Elevation Myocardial Infarction (NSTEMI) and an acute or chronic kidney disease (CKD) with a GRACE score \< 140. It should be determine if a prompt coronary angiography or the protection of the kidneys from the used contrast agent is more important for the outcome of the patients. Additionally it will be investigated if the ischemic precondition can help to prevent heart damages.

Detailed description

According to international guidelines a coronary angiography has to be performed within 72h for patients with (NSTEMI). Patients with a GRACE score \> 140 belong to the high risk group and the coronary angiography has to be performed within 24h. Until today for patients with a GRACE score \> 140 and an acute or chronic kidney disease (CKD) the best approach is not known even though up to 40% of all NESTMI patients belong to this population. CKD in connection with an NSTEMI is one predictor for short and long term mortality and serious bleeding as a complication of coronary angiography. Additionally patient with CKD are at risk to experience a contrast agent induced aggravation of the CKD right up to a kidney failure. The pre- and post treatment of the kidneys seem to reduce this risk. The irrigation of the kidneys up to 48h prior coronary angiography optimises the kidney function and buffers the aggravation of kidney function caused by fluid loss or abstention at home. Additionally the influence of ischemic precondition on one arm of the patient will be evaluated in this setting. First studies give a hint that the kidneys may be protected against the contrast agent of the following catheter examination by ischemic precondition.

Conditions

• Non-ST-segment Elevation Myocardial Infarction
• Chronic Kidney Disease

Interventions

Type	Name	Description
PROCEDURE	coronary angiography
PROCEDURE	ischemic precondition	four cycles of congestion and flow of blood in the arm of the patient for 5 minutes
PROCEDURE	prior kidney irrigation

Timeline

• Start date: 2015-09-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2015-09-07
• Last updated: 2016-10-05

Locations

1 site across 1 country: Germany