NCT02542280

Does Endometrial Injury Improve Intrauterine Insemination Outcome?

Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 360 (actual)
• Sponsor: Ain Shams Maternity Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 38 Years
• Healthy volunteers: Not accepted

Summary

The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.

Detailed description

In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome. Little is known about the efficacy of this procedure in improving intrauterine insemination outcome. Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.

Conditions

• Infertility

Interventions

Type	Name	Description
PROCEDURE	endometrial injury.	Endometrial injury using a pipelle biopsy catheter on day (5, 6 or 7) of the stimulation cycle combined with the intrauterine insemination.
PROCEDURE	intrauterine insemination	Placement of washed sperm in the uterus using a catheter, around the time of ovulation.
DRUG	ovarian stimulation	Inducing ovulation by human menopausal gonadotrophin ampoules given intramuscular starting from cycle day two, till the leading follicle reaches 16 - 18 mm.

Timeline

• Start date: 2013-07-01
• Primary completion: 2015-07-01
• Completion: 2015-09-01
• First posted: 2015-09-07
• Last updated: 2016-01-08
• Results posted: 2016-01-08