NCT02539641

Bariatric Procedures and Changes in Incretins and Gastric Emptying

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 32 (actual)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the placement of a duodenal-jejunal bypass liner. Additional, after bariatric surgery gut hormones that influence the gastric emptying rate are determined.

Detailed description

Bariatric surgery reduces stomach volume and passage of foods through the gastrointestinal tract is altered. The satiety level often increases, which is probably caused by gut hormones. Patients response on different bariatric procedures varies widely and it is difficult to predict which patient responds well. Possibly, patients who have successful excess weight loss (EWL) two years after surgery have different gastric emptying rates compared to unsuccessful patients. Changes in gut hormones after implantation of a duodenal-jejunal bypass liner were demonstrated in other studies. However, gastric emptying before and after placement of this liner is unknown.

Conditions

• Morbid Obesity

Interventions

Type	Name	Description
RADIATION	Gastric emptying scintigraphy	Scintigraphy is performed to evaluate gastric emptying after eating a pancake labeled by 20 megabecquerel (MBq) Technetium-99m-Albumin (TC-99m-LyoMAA)
OTHER	Determination of gut hormones	Gut hormone levels will be determined after eating a standard meal in the RYGB and SG groups.

Timeline

• Start date: 2015-04-01
• Primary completion: 2015-09-01
• Completion: 2016-05-01
• First posted: 2015-09-03
• Last updated: 2017-03-28

Locations

1 site across 1 country: Netherlands