Trials / Completed
CompletedNCT02538211
The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 63 (actual)
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Academic / Other
- Sex
- Male
- Age
- 18 Years – 35 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to evaluate if the intestinal microbiota influences rotavirus vaccine immune responses in healthy adult volunteers.
Detailed description
This study will alter the intestinal microbiota in healthy adults using antibiotics and subsequently measure immune reactions to the rotavirus vaccine (Rotarix), the tetanus vaccine and the pneumococcal vaccine (Pneumo23).
Conditions
- Rotavirus Infections
- Intestinal Bacteria Flora Disturbance
- Reaction - Vaccine Nos
- Tetanus
- Streptococcal Pneumonia
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | Rotavirus vaccine, Tetanus vaccine and Pneumococcal vaccine | All subjects will be given an oral dose of the rotavirus vaccine, RotarixTM, and intramuscular injections of the Tetanus vaccine and Pneumococcal vaccine, Pneumo 23. |
Timeline
- Start date
- 2015-09-01
- Primary completion
- 2017-01-01
- Completion
- 2017-02-01
- First posted
- 2015-09-02
- Last updated
- 2017-07-25
Locations
1 site across 1 country: Netherlands
Source: ClinicalTrials.gov record NCT02538211. Inclusion in this directory is not an endorsement.