NCT02536014

Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: Yonsei University · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Not accepted

Summary

Sympathetic activity could be increased during robot-assisted laparoscopic radical prostatectomy, which is performed in a steep trendelenburg position under CO2 pneumoperitoneum. Stimulation of the sympathetic nervous system prolongs the QT interval and can increases the susceptibility to life threatening cardiac arrhythmias. Dexmedetomidine has sympatholytic effects and potential antiarrhythmic properties. Perioperative administration of dexmedetomidine is a potential preventive and treatment strategy for tachyarrhythmia. Thus the investigators decided to evaluate the effect of dexmedetomidine on heart-rate corrected QT interval during robot-assisted laparoscopic radical prostatectomy. Furthermore, the investigators evaluated the Tp-e, Tp-e/QT ratio and Tp-e/QTc ratio as well.

Conditions

• Prostate Cancer
• Robotic Surgery

Interventions

Type	Name	Description
DRUG	Dexmedetomidine	Dexmedetomidine infusion (0.3㎍/kg/hr) from anesthetic induction to the end of pneumoperitoneum
DRUG	Saline	Saline infusion during the same time period

Timeline

• Start date: 2015-08-01
• Primary completion: 2016-01-01
• Completion: 2016-01-01
• First posted: 2015-08-31
• Last updated: 2016-01-29

Locations

1 site across 1 country: South Korea