NCT02535156

Schizotypal Personality Disorder Risperidone

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Neurophysiological indices of self-monitoring were assessed in a group of patients with Schizotypal Personality Disorder (SPD) and a control group. Both groups were assessed after the administration of risperidone and placebo.

Detailed description

The electroencephalogram (EEG) was recorder while participants (SPD participants and controls) performed a behavioral task: the Eriksen Flanker Task. The continuous EEG was segmented, corrected for artifacts and averaged. A component of the event-related brain potential known as the error-related negativity (ERN) was identified and its amplitude quantified in microvolts. This procedure was conducted two hours after the administration of risperidone 1 mg and placebo (lactose) on two different experimental days and for each participant group (SPD patients and controls). The amplitude of the ERN after placebo was compared between groups to test for baseline (non-drug-induced) differences between patients and controls. The impact of risperidone on the amplitude of the ERN was compared between the two participant groups.

Conditions

• Schizotypal Personality Disorder

Interventions

Type	Name	Description
DRUG	Risperidone	1 mg Risperidone
DRUG	Placebo	Lactose Placebo

Timeline

• Start date: 2003-01-01
• Primary completion: 2014-01-01
• Completion: 2015-01-01
• First posted: 2015-08-28
• Last updated: 2017-08-11