NCT02526511

Perfusion Magnetic Resonance Imaging in Diagnosing Patients With Kidney Tumors

Pilot Study of Renal Neoplasms With Perfusion Magnetic Resonance Imaging

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Rutgers, The State University of New Jersey · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This pilot clinical trial studies perfusion magnetic resonance imaging in diagnosing patients with kidney tumors. Diagnostic procedures, such as perfusion magnetic resonance imaging, may help find and diagnose kidney tumors and predict and monitor a patient's response to treatment.

Detailed description

PRIMARY OBJECTIVES: I. To investigate the utility of perfusion magnetic resonance imaging (pMRI) as a diagnostic biomarker for the prediction of malignant vs. benign organ confined renal masses. II. To investigate the utility of pMRI as a therapeutic biomarker for monitoring tumor progression in patients undergoing treatment (ablation, surgery, specific systemic treatments such as interleukin 2 (IL-2) or vascular endothelial growth factor \[VEGF\]/vascular endothelial growth factor receptor \[VEGFR\]/mechanistic target of rapamycin \[mTOR\] targeted therapies) or active surveillance for organ confined or metastatic renal tumors. SECONDARY OBJECTIVES: I. To investigate the utility of pMRI to predict tumor grade and histologic subtype of organ confined kidney cancers. OUTLINE: Patients undergo dynamic contrast enhanced (DCE), dynamic susceptibility contrast (DSC), or arterial spin labeled (ASL) pMRI within 30 days of biopsy or surgery. Patients with organ confined tumors selected for active surveillance or surgery and patients with metastatic renal cell carcinoma undergo follow up pMRI at 1-6 months. After completion of study, patients are followed up within 48 hours.

Conditions

• Stage I Renal Cell Cancer
• Stage II Renal Cell Cancer
• Stage III Renal Cell Cancer
• Stage IV Renal Cell Cancer

Interventions

Type	Name	Description
PROCEDURE	Arterial Spin Labeling Magnetic Resonance Imaging	Undergo arterial spin labeled perfusion magnetic resonance imaging
PROCEDURE	Dynamic Contrast-Enhanced Magnetic Resonance Imaging	Undergo dynamic contrast-enhanced perfusion magnetic resonance imaging
PROCEDURE	Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging	Undergo dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging
PROCEDURE	Perfusion Magnetic Resonance Imaging	Undergo perfusion magnetic resonance imaging

Timeline

• Start date: 2015-04-15
• Primary completion: 2025-07-28
• Completion: 2025-09-07
• First posted: 2015-08-18
• Last updated: 2023-04-11

Locations

1 site across 1 country: United States