Trials / Completed
CompletedNCT02525185
Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy
Contractile Reserve in Dyssynchrony (CRID): A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 200 (actual)
- Sponsor
- Oslo University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Cardiac resynchronisation therapy (CRT) has been documented to be a powerful treatment in patients with severe congestive heart failure. However, 30-40% of patients receiving a CRT are non-responders. In this study the investigators will use a previously validated method to estimate myocardial segment work non-invasively by speckle-tracking echocardiography and blood pressure. Furthermore, cardiac magnetic resonance imaging (CMR) with late gadolinium enhancement (LGE) will be performed in feasible subjects. The main purpose of the study is to determine if myocardial work by echocardiography in combination with viability assessment by LGE-CMR can predict response to CRT.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Diagnostic interventions; PET, MRI, cardiac ultrasound. |
Timeline
- Start date
- 2015-09-01
- Primary completion
- 2018-07-01
- Completion
- 2023-08-01
- First posted
- 2015-08-17
- Last updated
- 2023-11-01
Locations
2 sites across 2 countries: Belgium, Norway
Source: ClinicalTrials.gov record NCT02525185. Inclusion in this directory is not an endorsement.