Trials / Completed
CompletedNCT02523989
The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The Relationship Between Genetic Polymorphism of Arsenic Methylation Enzymes, Arsenic Methylation Capability and Blood Metals, and Developmental Delays in Preschool Children
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 137 (actual)
- Sponsor
- Taipei Medical University · Academic / Other
- Sex
- All
- Age
- 2 Years – 12 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.
Detailed description
The investigators recruited children with developmental delays and children with normal development from Shin-Kong Ho-Su Memorial Hospital as controls. Information obtained from the interview included socioeconomic and basic demographic characteristics as well as children function, health condition, and quality of life. On the other hand, blood and urine samples of the participants were collected for the analysis of arsenic methylation related enzymes using polymerase chain reaction and restriction fragment length polymorphism. 2 ml blood were digested for the determination of mercury, lead and arsenic. The relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of were analyzed.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | study group | Explore the relationship of heavy metals and health related quality of life, including the relationship between the developmental delays and polymorphism of arsenic methylation enzymes, arsenic methylation capability and blood metals. Identify the interaction of children function, health condition, and quality of life and arsenic methylation and blood metals in children with developmental delays. |
Timeline
- Start date
- 2010-03-01
- Primary completion
- 2011-07-01
- Completion
- 2011-07-01
- First posted
- 2015-08-14
- Last updated
- 2015-08-14
Locations
1 site across 1 country: Taiwan
Source: ClinicalTrials.gov record NCT02523989. Inclusion in this directory is not an endorsement.